Oxyclozanide

Product Name: Oxyclozanide

Properties:

Description:
Oxyclozanide is a salicylanilide anthelmintic, used for the treatment and control of fascioliasis in cattle, sheep, and goats. The mechanism of action of oxyclozanide is the uncoupling of oxidative phosphorylation in flukes. It is formulated as an oral drench containing oxyclozanide only or in combination with levamisole hydrochloride or oxfendazole or as a powder to be incorporated in the feed. The recommended doses are 10 to 15 mg oxyclozanide/kg BW for cattle and 15 mg oxyclozanide/kg BW for sheep and goats. The application was amended to exclude sheep milk and goat tissues and milk.

Pharmacokinetics of Oxyclozanide:

• After oral administration oxyclozanide is slowly absorbed into the bloodstream. Maximum blood concentrations in sheep and cattle are reached about 24 hours after treatment. Oxyclozanide binds strongly and almost completely (>99%) to plasma proteins.
• Oxyclozanide is metabolized in the liver and excreted mainly through bile and feces (up to 80%). The rest in urine and <0.1% in milk, mostly as unchanged oxyclozanide. Excretion half-life in sheep is about 7 days. Oxyclozanide excretion in milk of lactating cows is rather low, and several oxyclozanide products are approved for use on dairy animals.

Mechanism of action of Oxyclozanide:
The molecular mode of action of salicylanilide, including oxyclozanide, is not completely elucidated. They all are uncouplers of the oxidative phosphorylation in the cell mitochondria, which disturbs the production of ATP, the cellular “fuel”. This seems to occur through suppression of the activity of succinate dehydrogenase and fumarate reductase, two enzymes involved in this process. This impairs the parasites motility and probably other processes as well.

How oxyclozanide works?
Oxyclozanide is a salicylanilide anthelmintic, used for the treatment and control of fascioliasis in cattle, sheep and goats. The mechanism of action of oxyclozanide is the uncoupling of oxidative phosphorylation in flukes.

Oxyclozanide and animal disease:
Oxyclozanide is a salicylanilide anthelmintic, used for the treatment and control of fascioliasis in cattle, sheep and goats. It is formulated as an oral drench containing oxyclozanide only or in combination with levamisole hydrochloride or oxfendazole or as a powder to be incorporated in the feed.